Tadhg Beirne is in line for his Six Nations debut with the Ireland team to play Wales on Saturday being named this afternoon.
The word from the camp is that second row Iain Henderson has a knee injury and that paves the way for the Munster player to step in at lock alongside James Ryan.
Ex-Scarlets man Beirne, 27, made his international debut during last summer's tour of Australia and has four caps.
There may also be a recall for flanker Sean O'Brien, who failed to make the match-day panel for Sunday's win over France.
A groin injury keeps Josh van der Flier out, while Dan Leavy, who hasn't played a game since Leinster's Pro14 meeting with Connacht on 22 December, is also in the mix for the Cardiff clash (2.45pm).
Rob Kearney, who was a late withdrawal last weekend, is likely return at full-back having recovered from a calf strain.
The front row is expected to remain unchanged with Cian Healy and Tadhg Furlong either side of captain Rory Best, who will make his final championship appearance.
Peter O'Mahony and CJ Stander are likely to retain their places in the back row although Jack Conan impressed off the bench last week, playing just under an hour.
The Conor Murray and Johnny Sexton partnership will remain intact, while Bundee Aki and Garry Ringrose should line out in the centre.
Jacob Stockdale and Keith Earls are likely to keep their wing berths.
Munster trio Niall Scannell, Dave Kilcoyne and John Ryan look set to cover the front row off the bench, with Ultan Dillane and Conan the other forward replacements.
Kieran Marmion may get his first taste of Six Nations action this year off the bench, with Jack Carty and Jordan Larmour covering the rest of the backline.
Follow Wales v Ireland on Saturday (kick-off 2.45pm) via the live blog on RTÉ.ie/Sport and the News Now App, or listen live on RTÉ 2fm, with commentary from Michael Corcoran and Donal Lenihan.