England have selected a destructive centre partnership of Ben Te'o and Manu Tuilagi for Saturday's Guinness Six Nations match against Italy.
It is the first time the powerful carriers of Pacific Islands heritage have started together with Henry Slade dropping to the bench to accommodate Tuilagi's switch to 13 and Te'o's inclusion at inside centre.
And continuing the theme of a bulldozing backline - the biggest of the Eddie Jones era - is Joe Cokanasiga's inclusion on the right wing after Jack Nowell failed to recover from a shoulder injury.
Cokanasiga will win his fourth cap after making his Six Nations debut against Wales in Cardiff, deploying his 6'4" and 18 stones frame outside a midfield duo that weigh in at a combined 34 stones.
The backline otherwise remains unchanged with Ben Youngs and Owen Farrell continuing at half-back in a selection that sees Dan Robson and George Ford overlooked once again.
In total there are five changes in personnel to the side dispatched 21-13 at the Principality Stadium on February 23, including Joe Launchbury's elevation to the starting XV after Maro Itoje lost his battle with a knee injury.
It was hoped that Itoje would recover from his medial ligament damage to fill the void created by Courtney Lawes' calf strain, but a setback in training means that Launchbury will pack down together for only the second time.
Ellis Genge starts at loosehead prop, forcing Ben Moon on to the bench, and Brad Shields displaces Mark Wilson at blindside flanker.
"Italy are a bit of an unknown quantity but when Conor allows them to play rugby they play well," Eddie Jones said, in reference to the Azzurri's no ruck tactics of two years ago.
"They have played terrific games in the Six Nations. They are fitter, physically stay in the contest a lot longer and they are quite unpredictable in the way they attack.
"We expect Italy to throw the ball around a bit so we are going to have to defend very well against their unpredictability and when we have got the ball, we have to use it wisely."
England: Elliot Daly, Joe Cokanasiga, Manu Tuilagi, Ben Te'o, Jonny May; Owen Farrell, Ben Youngs; Ellis Genge, Jamie George, Kyle Sinckler; Joe Launchbury, George Kruis; Brad Shields, Tom Curry, Billy Vunipola.
Replacements: Luke Cowan-Dickie, Ben Moon, Dan Cole, Nathan Hughes, Mark Wilson, Dan Robson, George Ford, Henry Slade
Italy coach Conor O'Shea named the following team to play England in Saturday's Six Nations game at Twickenham with the returning number 8 Sergio Parisse to captain the side.
Italy haven't recorded a Six Nations win since their last gasp win over Scotland in Murrayfield in 2015 but their displays have been much improved in 2019 with their average margin of defeat falling substantially on recent seasons.
However, their record against England remains dismal. They remain the only side Italy have yet to beat in their almost 20 seasons in the competition.
Italy: Jayden Hayward, Edoardo Padovani, Michele Campagnaro, Luca Morisi, Angelo Esposito; Tommaso Allan, Tito Tebaldi; Andrea Lovotti, Luca Bigi, Simone Ferrari; Federico Ruzza, Dean Budd; Sebastian Negri, Abraham Steyn, Sergio Parisse.
Replacements: Leonardo Ghiraldini, Cherif Traore, Tiziano Pasquali, David Sisi, Jake Polledri, Guglielmo Palazzani, Ian McKinley, Tommaso Castello