Ireland have named their training squad for Sunday's Six Nations clash with France and there is no place for either Sean Cronin or Robbie Henshaw, while the game comes too soon for Joey Carbery.
Hooker Cronin started his first Six Nations game against Italy in round three but failed to take his chance and Ulster's Rob Herring is included alongside captain Rory Best and Niall Scannell.
Leinster's Ross Byrne is back in the panel as one of four out-halves including Johnny Sexton, Jack Carty and Joey Carbery.
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While Carbery is named in the squad, forwards coach Simon Easterby said that the Munster man is a doubt as he continues to recover from a hamstring injury.
"Joey trained today and ran and conditioned pretty well. It might be just a little bit too soon for him," Easterby told RTÉ Sport.
"I'd say he's unlikely to feature this week. He's probably recovered quicker than we expected but if he is 50/50, you wouldn't play a player."
Flanker Dan Leavy is again ruled out with an ankle problem while scrum-half Kieran Marmion is back in coach Joe Schmidt's plans for the first time in 2019 following ankle surgery.
Henshaw, who missed out against Scotland and Italy with a dead leg, has not recovered as quickly as hoped and sits out the Aviva clash.
"They can be nasty if they don't quite get right," said Easterby. "It's treated quite cautiously when they're quite deep and fortunately for Rob, he's just not getting it right and the medics are working hard to try to improve that but again, that might not happen quick enough."
Easterby said it was "possible" that Henshaw and Leavy would be ready to face Wales on 16 March.
"It's about making sure they're right and ready to play and not compromising their return.
"With the short turnaround the week after, it would be great if we could have some fresh bodies coming back in, but it might be too soon for both of them."
Defending champions Ireland, who are third in the standings behind England and leaders Wales, will name their team for the match on Friday.
Rory Best (Banbridge/Ulster) 115 caps (c)
Tadhg Beirne (Lansdowne/Munster) 4 caps
Jack Conan (Old Belvedere/Leinster) 12 caps
Ultan Dillane (Corinthians/Connacht) 13 caps
Tadhg Furlong (Clontarf/Leinster) 31 caps
Cian Healy (Clontarf/Leinster) 86 caps
Iain Henderson (Queens University/Ulster) 43 caps
Rob Herring (Ballynahinch/Ulster) 7 caps
Dave Kilcoyne (UL Bohemians/Munster) 27 caps
Jack McGrath (St Marys College/Leinster) 54 caps
Jordi Murphy (Lansdowne/Ulster) 27 caps
Sean O’Brien (UCD/Leinster) 55 caps
Peter O’Mahony (Cork Constitution/Munster) 55 caps (vc)
Andrew Porter (UCD/Leinster) 13 caps
Quinn Roux (Galwegians/Connacht) 11 caps
Rhys Ruddock (Lansdowne/Leinster) 21 caps
James Ryan (UCD/Leinster) 15 caps
John Ryan (Cork Constitution/Munster) 17 caps
Niall Scannell (Dolphin/Munster) 12 caps
CJ Stander (Shannon/Munster) 29 caps
Josh van der Flier (UCD/Leinster) 16 caps
Bundee Aki (Galwegians/Connacht) 15 caps
Ross Byrne (UCD/Leinster) 2 caps
Joey Carbery (Clontarf/Munster) 18 caps
Jack Carty (Buccaneers/Connacht) 1 cap
Andrew Conway (Garryowen/Munster) 11 caps
John Cooney (Terenure College/Ulster) 7 caps
Keith Earls (Young Munster/Munster) 75 caps
Chris Farrell (Young Munster/Munster) 5 caps
Tom Farrell (Coolmine/Connacht) 0 caps
Rob Kearney (UCD/Leinster) 89 caps
Jordan Larmour (St Mary’s College/Leinster) 11 caps
Kieran Marmion (Galwegians/Connacht) 24 caps
Conor Murray (Garryowen/Munster) 70 caps
Garry Ringrose (UCD/Leinster) 18 caps
Jonathan Sexton (St Marys College/Leinster) 81 caps (vc)
Jacob Stockdale (Lurgan/Ulster) 17 caps
Follow Ireland v France on Sunday (kick-off 3pm) via the live blog on RTÉ.ie/Sport and the News Now App, or listen live on RTÉ 2fm, with commentary from Michael Corcoran and Donal Lenihan.