Lock Cory Hill has been ruled out of Wales' remaining Guinness Six Nations games due to an ankle injury.
Dragons forward Hill was hurt during Saturday's clash against England in Cardiff. He scored a try as Wales triumphed 21-13.
The Welsh Rugby Union said that Hill will miss the tournament remainder, with Grand Slam-chasing Wales facing Scotland at Murrayfield on 9 March, then Ireland in Cardiff seven days later.
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Hill, 27, has played a key role during Wales' 12-game unbeaten run that stretches back to February last year.
With Hill now sidelined, Adam Beard and Jake Ball are among the options as skipper Alun Wyn Jones' second-row partner in Edinburgh.
"Cory was outstanding on Saturday," Wales skills coach Neil Jenkins told WRU TV.
"He scored a try as well and is a fantastic player for us and a good guy to have around the squad, so he is certainly going to be a loss.
"But any loss is someone else's opportunity, and we have some fantastic players in that position as well.
"I am sad for Cory, but it is an opportunity for someone else."
Wales have beaten Scotland on four of their last five visits to Murrayfield, and they will head north as firm favourites for another win.
Jenkins added: "It will certainly be a tough game for us in two weeks' time.
"For us, there is one focus and one focus only, and that is Scotland. There is nothing else after that as far as we're concerned.
"So we need to prepare properly, prepare well and be ready for a really tough encounter, which I am sure we will get."