Gareth Anscombe will start at out-half for Wales in Saturday's Guinness Six Nations clash against England at the Principality Stadium.

Anscombe has been preferred to the more experienced Dan Biggar, with Wales head coach Warren Gatland naming a team showing just two changes from the side that beat France three weeks ago.

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Dragons lock Cory Hill replaces Adam Beard as skipper Alun Wyn Jones' second-row partner, while scrum-half Gareth Davies takes over from Tomos Williams, who was not considered due to injury.

Prop Samson Lee was also unavailable because of injury. Tomas Francis starts at tighthead and opposes his Exeter team-mate Ben Moon, with Dillon Lewis on bench duty.

Full-back Leigh Halfpenny again misses out following the concussion he suffered three months ago.

Scarlets star Halfpenny, who last played on 10 November when Wales beat Australia, trained with Wales this week but he is not involved in the match-day 23.

Only four players remain on starting duty from the much-changed team that defeated Italy last time out - full-back Liam Williams, wing Josh Adams, centre Jonathan Davies and back-row forward Josh Navidi.

And Davies is one of four survivors from the side that crushed England's Grand Slam hopes through a spectacular 30-3 win in 2013, being joined by captain Jones, wing George North and flanker Justin Tipuric.

Wales and England are the tournament's only two remaining unbeaten teams this season, with Saturday's encounter being billed by many as a Six Nations title eliminator.

Wales team: Liam Williams; George North, Jonathan Davies, Hadleigh Parkes, Josh Adams; Gareth Anscombe, Gareth Davies; Rob Evans, Ken Owens, Tomas Francis; Cory Hill, Alun Wyn Jones (captain);  Josh Navidi , Justin Tipuric, Ross Moriarty.

Replacements: Elliot Dee, Nicky Smith, Dillon Lewis, Adam Beard, Aaron Wainwright, Aled Davies, Dan Biggar, Owen Watkin.

Follow Italy v Ireland (3pm) via our liveblog on RTÉ.ie/sport and the News Now app, or listen to live national radio commentary on 2fm