Gregor Townsend has made four changes to the Scotland team ahead of their clash with Ireland in Murrayfield.
Blair Kinghorn, hat-trick hero against Italy last weekend, is relegated to the bench with the returning Sean Maitland slotting in for the 22-year old on the wing.
Injuries have forced a couple of changes up front with Simon Bergham replacing Willem Nel at prop while Josh Strauss takes Sam Skinner's place in the back-row.
There was better news for the Scots elsewhere on the injury front, Jonny Gray has recovered from a shoulder complaint to displace Ben Toolis.
Townsend said: "We picked up two injuries from last week with WP (Nel) and Sam (Skinner) missing out, which is disappointing for us and them, but have had a boost with a number of proven Test players returning from injury and available to us this week.
"To have that calibre of player and experience around the group in the build-up this week, and during a game of such magnitude, is very important.
"Saturday's game is massive. It's probably the biggest challenge we'll face in the Guinness Six Nations, given the way Ireland have been playing in the last few years - they are Grand Slam champions and the number two team in the world.
"They're very well coached, have some outstanding players and will test us in a number of areas - defensively, set-piece, attack and kicking game. It is a challenge that brings an extra edge and focus to training and something our players relish taking on.
"Our players have risen to the challenge of playing New Zealand, England and other world class teams and they are aware that we must rise once more to produce one of our best-ever performances for 80 minutes."
Scotland, still seeking a first championship title since the final Five Nations in 1999, have beaten Ireland four times in the competition in the 21st century but did win the pair's last encounter in Murrayfield in 2017.
Scotland team v Ireland: S Hogg; T Seymour, H Jones, S Johnson, S Maitland; F Russell, G Laidlaw; A Dell, S McInally, S Berghan; G Gilchrist, J Gray; R Wilson, J Ritche, J Strauss.
Replacements: F Brown, J Bhatti, D Rae, B Toolis, R Harley, A Price, P Horne, B Kinghorn
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