Ireland will be without Garry Ringrose and Devin Toner for Saturday's Guinness Six Nations clash with Scotland at Murrayfield, but could be back to feature against Italy in round three.
Ireland travel to Scotland looking to avoid successive defeats following the 12-point loss to England, but will make at least three changes to the starting personnel.
Centre Ringrose is absent with a hamstring injury, while an ankle injury means James Ryan is likely to be partnered by Connacht's Quinn Roux on Saturday.
Ringrose's absence makes a return for Rob Kearney in Edinburgh more likely.
Robbie Henshaw played full-back against England but is likely to switch to outside centre in the absence of his Leinster team-mate.
CJ Stander had already been ruled out following a facial injury, though there is better news regarding winger Keith Earls.
The Munster winger was replaced at half-time after shipping a couple of heavy knocks last weekend, but could well be fit enough to face the Scots.
"Earlsy is pretty good," scrum coach Greg Feek told RTÉ Sport.
"It's a good sign at this stage. He's a tough character."
Feek said that the rest week following the second round of the competition would give Ringrose and Toner the opportunity to make a possible return against Italy, though that decision will be made in due course.
Munster lock Billy Holland has been called into the camp after the latest setback in the lock position and Feek gave an update on the fitness of Iain Henderson and Munster's Tadhg Beirne.
Henderson's thumb injury means he is battling to return for the end of the tournament, while Beirne was always pencilled in as a possibility for round three or four.
"Hendy is still a wee bit away," Feek said.
"He has a reputation for healing quite quickly. Tadhg could be right in a couple of weeks, but we will just have to wait and see."
Following the sobering loss last time out, Feek admits that Ireland will have to up their game if they are to get the better of a rejuvenated Scottish side.
"Part of it is just coming back to being Irish. There were parts of it at the weekend that didn't show that.
"All we can do now is focus on our accuracy and preparation for this week. That's our sole focus."
The post-mortems have taken place at the base camp at Carton House over where the champions fell short against Eddie Jones' side.
Notwithstanding collective and individual errors, the New Zealander insists it is such fine margins that decide victory and defeat in the international arena.
"We pride ourselves on playing a high-tempo game. Maybe there were a few key moments that we uncharacteristically didn't win. That's part of who we have been over the last few years, winning the next moment.
"Over the years, you talk about a loss being a good thing, but can't get over emotional about it. You have to get you preparation right, you have to back yourself.
"At Test match level, it can be a 5% difference from one game to the next, and that can be the difference in the result."
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