London Irish have confirmed they will move to the new Brentford Community Stadium for the 2020-21 season.
The Championship leaders, who are coached by former Ireland boss Declan Kidney, have reached an agreement with Brentford Football Club to play at the west London stadium, which is currently under construction and will have a capacity of 17,250.
It is due to open in 2020.
Irish have played at Reading's Madejski Stadium for the last 18 years.
The Reading facility is 30 miles away from Irish's training base in Sunbury, and they have had a long-held ambition to return to west London.
London Irish president Mick Crossan said: "In moving to the Brentford Community Stadium we feel confident that we will be able to attract a larger supporter base to join us as we build for the future.
"We are therefore very pleased to have agreed this deal with Brentford's management, and are looking forward to working closely with them to make the Brentford Community Stadium an outstanding home for us.
"The stadium will be an outstanding venue. It is the right size in a great location and will provide a superb match-day experience for our supporters and sponsors alike."
Brentford Community Stadium will be sited just north of Kew Bridge.