One week later than advertised, Joey Carbery is set to make his first start alongside Ireland half-back partner Conor Murray.
Having had to pull out of the home game after feeling a tight hamstring during the warm-up, the Ireland out-half is fit to face Castres in France on Saturday (kick off 5.30pm).
Carbery's inclusion in place of JJ Hanrahan is the one change from the XV that beat reigning Top 14 champions Castres 30-5 at Thomond Park in Pool 2 of the Heineken Champions Cup.
Murray is set to make his 120th Munster appearance and partners Carbery in the half-backs.
Mike Haley starts at full-back with Andrew Conway and Keith Earls completing the back three as Rory Scannell and Sammy Arnold continue their centre partnership.
The tight five are unchanged once again with Dave Kilcoyne, Niall Scannell and John Ryan in the front row as Tadhg Beirne and Billy Holland pair up in the engine room.
Peter O’Mahony captains the side from the back row with Chris Cloete and CJ Stander completing the side.
Stephen Archer is included among the replacements after missing out last week through illness.
Munster top the pool with 11 points, three ahead of Gloucester and a win away to Castres would be a massive boost ahead of the busy festive period.
Castres: Scott Spedding; Martin Laveau, Thomas Combezou, Florian Vialelle, Taylor Paris; Benjamin Urdapilleta, Rory Kockott; Paea Fa'anunu, Kevin Firmin, Marc Clerc; Thibault Lassalle, Loic Jacquet; Yannick Caballero, Mathieu Babillot, Maama Vaipulu
Replacements: Marc-Antoine Rallier, Antoine Tichit, Wilfried Hounkpatin, Christophe Samson, Kevin Gimeno, Robert Ebersohn, Armand Batlle, Ludovic Radosavljevic
Munster: Mike Haley; Andrew Conway, Sammy Arnold, Rory Scannell, Keith Earls; Joey Carbery, Conor Murray; Dave Kilcoyne, Niall Scannell, John Ryan; Tadhg Beirne, Billy Holland; Peter O’Mahony (C), Chris Cloete, CJ Stander.
Replacements: Kevin O’Byrne, Jeremy Loughman, Stephen Archer, Fineen Wycherley, Arno Botha, Alby Mathewson, JJ Hanrahan, Jaco Taute.
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