Adam Griggs has named two debutants for Sunday’s Test match with USA in Energia Park at 1.00pm, with 16-year-old Beibhinn Parsons in line to make history from the bench.
Laura Sheehan and Lauren Delany will make their first Ireland appearances.
Lindsay Peat makes her 23rd appearance at loose-head in the front row, and packs down alongside hooker Sarah Mimnagh, who makes her return to the green jersey having last lined out for Ireland during the 2015 Women's Six Nations. Fiona Reidy completes the front-row.
The second-row is comprised of Aoife McDermott and Ciara Cooney, and the back-row sees Edel McMahon alongside the experienced duo of Claire Molloy and captain Ciara Griffin.
Railway Union RFC provide the half-back partnership in scrum-half Ailsa Hughes and out-half Nikki Caughey, with Michelle Claffey and Sene Naoupu forming the centre partnership.
The back-three has two new caps in full-back Delany and winger Sheehan.
Sheehan's UL Bohs club-mate Eimear Considine starts on the opposite wing.
There are also two uncapped players amongst the replacements, with St.Mary's College hooker Emma Hooban and Ballinasloe's Parsons looking to win their first caps on Sunday afternoon.
Parsons will become the youngest player to wear the green jersey in an International test match in the modern era as she turns 17 later this month.
Looking ahead to the Donnybrook encoiunter, Griggs said: "We've named what we believe to be an exciting side for this weekend's game, with a blend of experienced players along with some new faces who have impressed across the Women's AIL and the Interpro series.
"We've had some really good preparation over the last two months in camp and the competition amongst the squad has really driven our standards, which in turn has raised the quality of our rugby throughout the side.
"Selections were not an easy task and the players chosen to represent our squad and the jersey this week have stood up and worked hard to earn their selection.
"This will be the USA's third game in as many weeks, Which I'm sure has given them the chance to bond and gel as a squad.
"They had two tough games against the Black Ferns and England that they will certainly have learnt a lot from and come Sunday there is no doubt they will be match ready for us which will be the challenge we must rise to from the start.
"It's an exciting two weeks for this squad and we hope to see a big turn out on Sunday in Energia Park to support the team."
Ireland: Lauren Delany, Eimear Considine, Sene Naoupu, Michelle Claffey, Laura Sheehan, Nikki Caughey, Ailsa Hughes
Lindsay Peat, Sarah Mimnagh, Fiona Reidy, Aoife McDermott, Ciara Cooney, Edel McMahon, Claire Molloy, Ciara Griffin
Replacements: Emma Hooban, Laura Feely, Leah Lyons, Nichola Fryday, Jeamie Deacon, Nicole Cronin, Claire McLaughlin, Beibhinn Parsons