Billy Vunipola will miss England's autumn Test campaign after breaking his left arm.
The Saracens number eight suffered his latest injury in Sunday's 13-3 Champions Cup win at Glasgow, and will undergo surgery on Tuesday.
It is the third time Vunipola has broken his arm in this year alone. This time it is his left arm that has incurred the injury. He had previously broken his right arm in January and again in June.
The No. 8 missed England's - ultimately abject - Six Nations defence with the initial broken arm and is now out for their November clashes against South Africa, New Zealand, Japan and Australia.
"Billy has fractured his left arm and will have surgery on Tuesday. He is expected to be out of action for around 12 weeks," confirmed Saracens in a statement.
Prop Mako Vunipola's calf strain and lock Nick Isiekwe's ankle sprain will also hand England boss Eddie Jones further headaches, with both now also huge doubts to take part in England's autumn schedule.
