Sean O'Brien will make his first start of the season for Leinster when they welcome Munster to the Aviva Stadium in the Pro14 on Saturday.
The Ireland international played only six games in an injury-marred campaign last season but has recovered from shoulder surgery and played 55 minutes off the bench in the 20-3 win at Connacht last weekend.
It will be a memorable day for Rob Kearney as he will win his 200th cap for the province. He made his debut in September 2005 away to the Ospreys scoring a try in a 22-20 loss.
Since then he has become one of the most decorated players in Irish rugby with 199 Leinster caps, 86 Ireland caps and eight caps for the British & Irish Lions.
Luke McGrath, who has been named amongst the replacements, is due to win cap 100 if introduced.
With Kearney in the number 15 jersey, Fergus McFadden is on the right wing with James Lowe on the left.
Robbie Henshaw and Rory O'Loughlin are selected in the centre with Jamison Gibson-Park and Ross Byrne in the half backs.
Jack McGrath makes his first appearance of the season at loose-head prop having recovered from a knee injury. James Tracy and Michael Bent complete the front row.
Devin Toner becomes the third highest capped Leinster player of all time as he wins cap 222 in the second row with James Ryan beside him.
Rhys Ruddock captain the side from the back row with Dan Leavy and O'Brien completing the pack.
Leinster: Rob Kearney; Fergus McFadden, Rory O'Loughlin, Robbie Henshaw, James Lowe; Ross Byrne, Jamison Gibson-Park; Jack McGrath, James Tracy, Michael Bent; Devin Toner ,James Ryan; Rhys Ruddock (capt), Dan Leavy, Seán O'Brien.
Replacements: Sean Cronin, Cian Healy, Andrew Porter, Mick Kearney, Josh van der Flier, Luke McGrath, Noel Reid, Dave Kearney.
Munster head Coach Johann van Graan has made three changes for the derby (kick-off 6pm, live on RTÉ Radio 1) from the side that secured a record Pro14 win over Ulster last weekend at Thomond Park.
Jean Kleyn comes into the second row in the only change to the pack with Darren Sweetnam and Sammy Arnold joining the backline.
Andrew Conway is set to make his 100th Munster appearance in the clash.
Peter O’Mahony captains the side in an unchanged back-row with two-try Tommy O’Donnell and CJ Stander keeping their places. Conway starts at full-back with Sweetnam and Keith Earls on either flank.
Dan Goggin, a standout in the Ulster win with a two-try performance, is joined by Arnold in the centres.
The half-back pairing is unchanged as Joey Carbery is partnered by Alby Mathewson.
Front row trio Dave Kilcoyne, Niall Scannell and Stephen Archer are also retained with Kleyn coming in to partner Tadhg Beirne in the engine room.
Munster: Andrew Conway; Darren Sweetnam, Sammy Arnold, Dan Goggin, Keith Earls; Joey Carbery, Alby Mathewson; Dave Kilcoyne, Niall Scannell, Stephen Archer; Jean Kleyn, Tadhg Beirne; Peter O’Mahony (C), Tommy O’Donnell, CJ Stander.
Replacements: Kevin O’Byrne, James Cronin, Ciaran Parker, Billy Holland, Chris Cloete, Duncan Williams, JJ Hanrahan, Rory Scannell.
Follow Leinster v Munster with our live match tracker on RTÉ.ie/sport or listen to live radio commentary on RTÉ Radio 1's Saturday Sport.
