Tommy Bowe has been ruled out of Ireland's Six Nations clash with England after suffering a suspected fracture of his left leg.
Fergus McFadden has been drafted into the Ireland squad to fill the gap left by Bowe and as of yet, there's no time frame for the Ulsterman's return.
"It's a suspected fracture. We wish Tommy all the best and a speedy recovery," team manager Paul Dean said.
"It was very unfortunate. I don't think he was even on for a minute. We're really sorry for him."
Elsewhere Conor Murray and Jared Payne have both been passed fit to face England this Saturday.
Murray had to go off the pitch early in the second half against Wales with a stinger arm injury but he will be in full training this week.
"Conor's fine," Dean added. "He got a stinger. The full power (of the arm) is slow to come back. It didn't come back quickly enough for him to stay on the pitch but it's come back 100% now.
"Iain Henderson had a very similar injury against France. The power returned almost immediately for Iain and he was able to stay on no problem. With Conor, it delayed a little bit too long and we had to take him off."
Meanwhile Jonny Sexton underwent a precautionary head injury assessment after suffering a blow to the head against Wales but he has been given the all clear.
"He has a big black eye," Dean said of the outhalf. "With any contact to the head there will be a HIA done. There are three stages to that; one, two and three. He came through all three of them no problem and there's no concern for concussion."
