Connacht will have to plan without Marnitz Boshoff for the next three months after the South African underwent shoulder surgery.
The injury occurred against Treviso two weeks ago and the province have confirmed that he is expected to miss 12 weeks of action.
Cian Kelleher sustained a hamstring injury in the Champions Cup loss to Wasps and will be out for up to four weeks.
Connacht host Wasps in the Sportsground on Saturday (5.30pm) and are also monitoring the fitness of Jake Heenan and Stacey Ili.
Meanwhile, Pat Lam has added flanker Fijian back-row Naulia Dawai to his Champions Cup roster, Eoin Griffin has been deregistered.
