Wales flanker Dan Lydiate is a doubt for the Six Nations after suffering knee ligament damage.
The 28-year-old Ospreys back-rower was carried off on a stretcher during Wales' 27-13 win over South Africa last weekend and is set for a spell of two to three months on the sidelines.
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Ospreys head coach Steve Tandy told BBC Wales Sport: "It's not great, there's definitely some ligament damage. It will be a bit more than a couple of months.
"The worst thing is for Dan, it's off the back of some bad luck with injuries and he was starting to come back into a bit of form.
"Ultimately I'm just disappointed for the boy, whoever he was playing for, Wales or Ospreys.
"I'm just pretty gutted for Lyds."
Ireland play Wales in round 4 on 10 March in Cardiff.