Head coach Tom Tierney is looking forward to what he reckons could be "the biggest season in the history of Ireland's women's rugby."
The side face England on Sunday (UCD, 2pm, live on Irish Rugby TV) in the first November international series.
The three-match run (Canada, 19 November, New Zealand, 27 November) comes nine months ahead of the World Cup, which is being held in Ireland.
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Tierney said: "This weekend marks the first game of what is arguably going to be the biggest season in the history of Ireland's Women's Rugby.
The World Cup is now less than nine months away, and while there a lot of rugby to be played between now and then, the players are very eager to run out at UCD this Sunday and get things under way in our first ever November Series.
"We're without some of our more experienced players this weekend, but this gives other members of the squad the opportunity to develop their game and get some much needed experience themselves.
"Starting this weekend, we'll play three games in three weeks against some very competitive opposition and this is important as we prepare for the pool games of the World Cup in UCD.”
Captain Niamh Briggs is one of those side-lined as she continues to rehab an injured hamstring injury she picked up in a recent club game, however, he has named an exciting squad with one new cap in the starting 15, Connacht centre Nicole Fowley, and two more new caps on the bench.