Robbie Henshaw will make his debut for Leinster in today's derby clash at the Aviva Stadium, while Munster captain Peter O’Mahony has been named to start.
Showing no ill effects from his return to competitive action last weekend, flanker O’Mahony is one of three personnel changes to the visitors' pack with Niall Scannell and John Ryan returning to the front row for the Guinness Pro12 tie (2.05pm, live on RTÉ Radio 1).
In the backs, Rory Scannell has successfully rehabbed the neck injury he sustained against Cardiff in round 2 to start alongside Keith Earls in the centre for the first time this season.
The final change sees Ronan O’Mahony start on the left wing.
Munster: Simon Zebo; Darren Sweetnam, Keith Earls, Rory Scannell, Ronan O’Mahony; Tyler Bleyendaal, Conor Murray; Dave Kilcoyne, Niall Scannell, John Ryan; Donnacha Ryan, Billy Holland; Peter O’Mahony (capt), Tommy O’Donnell, CJ Stander.
Replacements: Duncan Casey, James Cronin, Stephen Archer, Robin Copeland, Jack O’Donoghue, Duncan Williams, Ian Keatley, Jaco Taute.
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Meanwhile, Rob Kearney comes back from a knee injury sustained in the Round 2 game against Glasgow Warriors to take up his place at full-back for the hosts, with Rory O'Loughlin on the right wing for his first home start.
Garry Ringrose comes back into the number 13 jersey having missed the trip to Cardiff and Henshaw makes his debut beside him at 12.
The 23-year-old who joined Leinster in the summer has 22 caps for Ireland and is returning from a shoulder injury picked up on the Ireland tour to South Africa in the summer.
Luke McGrath comes back in to the starting 15 with Johnny Sexton outside him after his Man of the Match performance last weekend.
In the pack it's a new front row with Irish internationals Cian Healy, Sean Cronin and Tadhg Furlong packing down.
Devin Toner is partnered in the second row by Cork native and former Munster player Ian Nagle who makes his first home appearance for Leinster.
Leinster: Rob Kearney, Rory O'Loughlin, Garry Ringrose, Robbie Henshaw, Isa Nacewa (capt), Johnny Sexton, Luke McGrath; Cian Healy, Sean Cronin, Tadhg Furlong, Devin Toner, Ian Nagle, Rhys Ruddock, Jordi Murphy, Jamie Heaslip.
Replacements: James Tracy, Jack McGrath, Mike Ross, Ross Molony, Dan Leavy, Jamison Gibson-Park, Joey Carbery, Noel Reid.
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