Flanker Sam Jones is expected to miss England's autumn internationals after breaking his right leg in training.
Wasps confirmed the 24-year-old suffered a fracture to his right fibula during England's training camp in Brighton.
Jones had been in contention to feature at openside flanker in England's November series, but must now instead wait to discover how long he will be sidelined.
Jones' injury almost certainly denies him the chance to compete with Leicester's Mike Williams for first refusal on England's vacant number seven shirt.
Wasps' James Haskell remains sidelined after toe surgery, leaving the openside role up for grabs. England boss Eddie Jones wants a "destructive defensive player" at seven in the absence of a "natural" openside.
Saracens' versatile lock Maro Itoje could yet move out to the flank, with Chris Robshaw continuing at blindside and Billy Vunipola at number eight.
Wasps flanker Jones' impending absence cuts Eddie Jones' resources once more though, with the England boss able to draft a replacement into his 45-man Elite Player Squad (EPS) if required.
Wasps' Guy Thompson was thought to have only narrowly missed the initial England call, so could now feature prominently in head coach Jones' thinking for how to cover this latest injury setback.