Irish internationals Matt Healy, Kieran Marmion, Finlay Bealham, Quinn Roux and Ultan Dillane have been named in the Connacht team to play Scarlets on Saturday.
Along with Roux, Jake Heenan will make a welcome return from injury and his first appearance of the season.
Dillane starts in the back row for the first time along with Heenan and captain John Muldoon, whose side, the reigning Pro12 champions, are still looking for their first win.
Head coach Pat Lam said: "With more guys coming back from injury, it's pleasing to be able to select a bit more experience in our side.
"Quinn (Roux) and Jake (Heenan) returning is obviously a boost and it helps drive more competition within the squad.
"Although we have never won at Parc y Scarlets before, we are really excited by the challenge to try and create a small bit of history.
"While both teams are obviously determined to get points on the table, our focus remains on the quality of our performance."
Connacht: Tiernan O'Halloran, Niyi Adeolokun, Bundee Aki, Eoin Griffin, Matt Healy, Jack Carty, Kieran Marmion; Denis Buckley, Tom McCartney, Finlay Bealham, Quinn Roux, Andrew Browne, Ultan Dillane, Jake Heenan, John Muldoon (capt).
Replacements: Dave Heffernan, Ronan Loughney, JP Cooney, Lewis Stevenson, Eoin McKeon, Caolin Blade, Shane O'Leary, Cian Kelleher.
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Munster director of rugby Johan Erasmus has made five personnel changes for tomorrow's Guinness Pro12 round 4 encounter against Edinburgh at Thomond Park with centre Cian Bohane in line to make his first competitive start for the province.
Bohane's inclusion in the starting XV sees the Corkman form a brand new centre partnership with returning international Keith Earls who has made a speedy recovery from the tight hamstring that saw him withdrawn from last weekend's encounter in Newport.
Elsewhere, Dave Kilcoyne will make his first start of the season in the front row while the return of Dave O'Callaghan at 6 sees captain Billy Holland - the Pro12's leading tackler to date - revert to the second row.
The final change comes in the back three with Ian Keatley to start at full-back. One of only three players to have scored in excess of 1000 points in the league (1266), Keatley needs just five points to reach the 1000 mark for Munster across all competitions.
Should he appear from the bench, recent academy graduate and Ireland Men's 7s representative Alex Wotton will make his first competitive appearance.
Successfully rehabbing a neck injury, Stephen Archer is included in the matchday squad for the first time this season.
Munster: Ian Keatley, Darren Sweetnam, Keith Earls, Cian Bohane, Ronan O'Mahony, Tyler Bleyendaal, Conor Murray; Dave Kilcoyne, Niall Scannell, John Ryan, Jean Kleyn, Billy Holland (capt), Dave O'Callaghan, Jack O'Donoghue, CJ Stander.
Replacements: Duncan Casey, James Cronin, Stephen Archer, Donnacha Ryan, Conor Oliver, Duncan Williams, Dan Goggin, Alex Wootton.
