Uncapped props Zander Fagerson and Rory Sutherland have been named in Vern Cotter's 35-man Scotland squad for the Six Nations, while centre Alex Dunbar makes his return after a year out injured.
Glasgow centre Dunbar spent 10 months out after a knee injury killed off his hopes of featuring at last year's World Cup.
However, there is no place for his Warriors team-mate Ryan Wilson, who faces a potentially lengthy ban after being cited for allegedly grabbing the testicles of Northampton's scrum-half Lee Dickson.
Ireland host Scotland on the last day of fixtures on 19 March.
YOUR @Scotlandteam forwards for the 2016 @rbs_6_nations | #AsOne pic.twitter.com/SiCdtveH7r
— Scottish Rugby (@Scotlandteam) January 19, 2016
Glasgow tighthead Fagerson is 20 on Wednesday, while 23-year-old Sutherland has earned a shot after a strong start to the season for Edinburgh.
Prop Moray Low and hooker Pat MacArthur are also included after missing out on the World Cup, where Scotland agonisingly lost to Australia in the quarter-finals.
YOUR @Scotlandteam backs for the 2016 @rbs_6_nations | #AsOne pic.twitter.com/opYtaAdjNt
— Scottish Rugby (@Scotlandteam) January 19, 2016
There are 23 World Cup squad members retained, with six unavailable through injury or retirement.
Back into the frame also comes Duncan Taylor, who missed the World Cup through injury, as does flanker John Barclay, a surprise omission last year.
"We've selected a mixture of experience with some exciting young players coming through, some of whom have experienced the Rugby World Cup and are eager to move forward, take the Six Nations head on and show that we can develop our game and be competitive," Cotter said in a statement.
"I think there should be confidence. The guys have worked hard and improved.
"There are positive signs that we can compete, and this championship will give us another opportunity to measure ourselves against very good opposition in a tough competition."
The new props are among four changes to Scotland's front-row options originally named for England 2015, with 29-times capped Exeter Chiefs' Low, and six-times capped Glasgow Warriors' MacArthur returning to Cotter's group for the first time since the summer of 2014.
Ben Toolis will also look to add to the solitary cap he has won at lock, while back-rower Chris Fusaro is included after an 18-month exile.
In the backs, Dunbar hopes to bounce back after the cruciate ligament nightmare he suffered ahead of last year's Calcutta Cup clash with England.
Saracens centre Matt Taylor and Wasps fly-hald Ruaridh Jackson are also given reprieves after missing out on the World Cup.
Cotter has once again picked Gloucester scrum-half Greig Laidlaw to lead the side out.
Cotter has his injury concerns, though, with prop Jon Welsh, hooker Fraser Brown, lock Grant Gilchrist, scrum-half Henry Pyrgos and centre Richie Vernon - who all featured at the World Cup - currently unavailable.
However, Gilchrist and Pyrgos have been invited to train with the squad when it meets for a pre-Championship camp in St Andrews this Sunday to help boost their recoveries.
Scotland, who finished last in 2015 after losing every game, kick off the tournament at home to England on 6 February.
Forwards: Hooker Ross Ford (Edinburgh Rugby) - 94 caps Pat MacArthur (Glasgow Warriors) - 6 caps Stuart McInally (Edinburgh Rugby) - 2 caps Front row Alasdair Dickinson (Edinburgh Rugby) - 52 caps Zander Fagerson (Glasgow Warriors) - uncapped Moray Low (Exeter Chiefs) - 29 caps Willem Nel (Edinburgh Rugby) - 8 caps Gordon Reid (Glasgow Warriors) - 15 caps Rory Sutherland (Edinburgh Rugby) - uncapped Lock Jonny Gray (Glasgow Warriors) - 19 caps Richie Gray (Castres) - 51 caps Tim Swinson (Glasgow Warriors) - 17 caps Ben Toolis (Edinburgh Rugby) - 1 cap Back row Adam Ashe (Glasgow Warriors) - 6 caps John Barclay (Scarlets) - 45 caps Blair Cowan (London Irish) - 15 caps David Denton (Bath) - 32 caps Chris Fusaro (Glasgow Warriors) - 4 caps John Hardie (Edinburgh Rugby) - 5 caps Josh Strauss (Glasgow Warriors) - 5 caps
Backs: Scrum-half Sam Hidalgo-Clyne (Edinburgh Rugby) - 8 caps Greig Laidlaw (captain) (Gloucester) - 46 caps Stand-off Finn Russell (Glasgow Warriors) - 15 caps Duncan Weir (Glasgow Warriors) - 21 caps Centre Mark Bennett (Glasgow Warriors) - 13 caps Alex Dunbar (Glasgow Warriors) - 14 caps Peter Horne (Glasgow Warriors) - 15 caps Matt Scott (Edinburgh Rugby) - 33 caps Duncan Taylor (Saracens) - 12 caps Wing Sean Lamont (Glasgow Warriors) - 101 caps Sean Maitland (London Irish) - 20 caps Tommy Seymour (Glasgow Warriors) - 22 caps Tim Visser (Harlequins) - 23 caps Full-back Stuart Hogg (Glasgow Warriors) - 38 caps Ruaridh Jackson (Wasps) - 27 caps
