Connacht head coach Pat Lam has made 12 personnel and two positional changes ahead of Ulster's visit to the Sportsground, as injuries mount.
Niyi Adeolokun, who switches from the left to right wing, and November Player of the Month Craig Ronaldson are the only two remaining from the backline that started against Newcastle on Sunday.
Galway man Tiernan O'Halloran returns to take his place at full back while Ronaldson is joined in the centre by the returning Bundee Aki. Matt Healy returns to start on the left wing while the half back pairing sees Jack Carty and Kieran Marmion line out together for the seventh time this season.
Up front, only Eoghan Masterson remains from last week, switching to Number 8 to allow captain John Muldoon return at blindside flanker, while Academy flanker James Connolly completes the back row.
Ultan Dillane and Aly Muldowney form the second row partnership behind the new front row trio of Finlay Bealham, Dave Heffernan and Ireland international Nathan White.
On the bench, both Ronan Loughney and AJ MacGinty have been passed fit for inclusion in this week's match day squad. Academy players Shane Delahunt, Sean O'Brien and Rory Parata are also included among the replacements.
Connacht: Tiernan O'Halloran, Niyi Adeolokun, Bundee Aki, Craig Ronaldson, Matt Healy, Jack Carty, Kieran Marmion, Finlay Bealham, Dave Heffernan, Nathan White, Ultan Dillane, Aly Muldowney, John Muldoon, James Connolly, Eoghan Masterson
Replacements: Shane Delahunt, Ronan Loughney, Rodney Ah You, Andrew Browne, Sean O'Brien, Ian Porter, AJ MacGinty, Rory Parata
Ulster have opted to rest Rory Best as Rob Herring replaces him as hooker and captain.
Andy Warwick will make his fifth start of the season at loosehead prop, with Wiehahn Herbst anchoring the other side of the scrum. While Alan O'Connor and Franco van der Merwe continue their second row partnership from the back-to-back wins over Toulouse.
There is one change in the back row, with Nick Williams coming in for Roger Wilson at number 8, while Robbie Diack and Sean Reidy are retained as the other loose forwards.
Rory Scholes is the only newcomer to the backline, replacing the injured Craig Gilroy on the left wing. Andrew Trimble is named on the right flank and Louis Ludik will again line out at fullback.
Stuart McCloskey and Luke Marshall will start together in midfield for the third consecutive outing, with Ruan Pienaar and Paddy Jackson in their usual half back positions.
Ulster: L Ludik, A Trimble, L Marshall, S McCloskey, R Scholes, P Jackson, R Pienaar; A Warwick, R Herring (captain), W Herbst, A O'Connor, F van der Merwe, R Diack, S Reidy, N Williams
Replacements: J Andrew, C Black, R Lutton, S Mulholland, R Wilson, P Marshall, I Humphreys, S Arnold.
