Conor Murray, Donnacha Ryan and Francis Saili have all come through this week's preparations in time to be included in Munster's team to take on Leicester Tigers on Saturday in Thomond Park.
Head Coach Anthony Foley has made nine changes to the side that started against Newport Gwent Dragons last Sunday.
In the front row James Cronin and BJ Botha return to scrum down on either side of hooker Niall Scannellwho makes his first European appearance this weekend.
The returning Ryan joins Dave Foley in the second row while Robin Copeland and CJ Stander are named alongside Dave O'Callaghan in the back row.
Named at blindside, this will be Copeland's first Champions Cup start for the province, while Stander returns to captain the side from number 8.
A changed half-back pairing sees Conor Murray and Ian Keatley renew their partnership after Murray successfully rehabbed a bruised bone he sustained during the round one encounter against Treviso.
The further changes to the backline see Saili, Keith Earls and Andrew Conway all named.
Saili starts with Denis Hurley in midfield while Simon Zebo is joined by Keith Earls and Andrew Conway in the back three.
Mike Sherry is included in the replacements following on from a knee injury he sustained in the opening round against Treviso while Tyler Bleyendaal is in line to make his European debut if sprung from the bench.
Munster: Andrew Conway; Keith Earls, Francis Saili, Denis Hurley, Simon Zebo; Ian Keatley, Conor Murray; James Cronin, Niall Scannell, BJ Botha; Dave Foley, Donnacha Ryan; Robin Copeland, Dave O'Callaghan, CJ Stander
Replacements: Mike Sherry, Dave Kilcoyne, John Ryan, Mark Chisholm, Jack O'Donoghue, Tomás O'Leary, Tyler Bleyendaal, Lucas Gonzalez Amorosino.
Leinster head Coach Leo Cullen has made six changes to the side to take on Toulon in a crucial Pool 5 clash in the Champions Cup on Sunday (kick off 3.15pm, live on RTÉ Radio 1).
With last weekend's game against the Glasgow Warriors falling victim to the elements Desmond, the starting XV has a number of changes to the team that played against Ulster in the RDS two weeks ago.
In the backs Fergus McFadden, Rob Kearney and Isaac Boss come in while in the pack it's a completely new front row.
Kearney starts at full-back in only his second game this season for the province since starting against Scarlets in the Guinness PRO12 in early November.
Fergus McFadden and captain Isa Nacewa have scored 81 points between them this season including four tries and start on the right and left wing respectively.
Luke Fitzgerald and Ben Te'o start in the centre with Isaac Boss partnering Johnny Sexton in the half backs.
Rhys Ruddock, Josh van der Flier and Jamie Heaslip retain their places in the back row while the second row is also unchanged from the Ulster game with Devin Toner partnering Mike McCarthy.
The front row sees a new combination of Cian Healy, Richardt Strauss and Mike Ross line up against the reigning European champions.
Ten of the starting XV also started in last season's agonising 25-20 semi-final extra time loss to Toulon in Marseille.
Leinster: Rob Kearney; Fergus McFadden, Ben Te'o, Luke Fitzgerald, Isa Nacewa (capt); Johnny Sexton, Isaac Boss; Cian Healy, Richardt Strauss, Mike Ross; Devin Toner, Mike McCarthy; Rhys Ruddock, Josh van der Flier, Jamie Heaslip.
Replacements: Sean Cronin, Jack McGrath, Marty Moore, Tom Denton, Jordi Murphy, Eoin Reddan, Ian Madigan, Dave Kearney.
Rory Best returns to captain Ulster for Friday's Champions Cup Pool 1 match against Toulouse at Kingspan Stadium, kick off 7.45pm.
Best starts in the front row alongside Wiehahn Herbst and Kyle McCall, who supporters recently voted as Ulster's Kingspan Player of the Month for November.
Alan O'Connor has been given the opportunity to start in the second row with the experienced Franco van der Merwe, while Robbie Diack, Chris Henry and Nick Williams will make up the loose forward trio.
There is a new centre partnership with Stuart McCloskey and Luke Marshall combining in midfield.
Craig Gilroy is recalled onto the left wing, with Andrew Trimble occupying the right wing berth and Louis Ludik completing the back three.
Ruan Pienaar and Paddy Jackson will continue to direct play from the half back positions.
Rob Herring, who led Ulster to a 14-7 PRO12 win over Edinburgh last weekend, is named on the replacements bench along with fellow forwards Andy Warwick, Ricky Lutton, Clive Ross and Roger Wilson. Paul Marshall and Ian Humphreys will again provide back up for Pienaar and Jackson, with Rory Scholes also included in the match day squad.
Ulster boss Les Kiss has described Toulouse as "predictably unpredictable" ahead of the game.
Both teams have already suffered at the hands of unbeaten Pool One leaders Saracens this season, and Ulster cannot afford a second successive home defeat if they are to retain serious quarter-final ambitions.
"They are predictably unpredictable," rugby director Kiss said, assessing four-time European champions Toulouse's threat.
"They have a massive squad that is full of internationals, so that gives them some really good options all over the park.
"They are second in the Top 14, so it's a huge challenge for us, but the boys have shown great character and we will step up to the plate.
"Losing can put you on the back foot, but it would be remiss of anyone to define a competition after two games. I don't think anyone's has been defined after round two in this competition before."
Ulster have a game in hand on Toulouse and Saracens after their appointment with Oyonnax last month was postponed following the Paris terror attacks, with that match now rearranged for 10 January.
And Kiss added: "Toulouse know it's a real battle for that second place, and you never know what could happen if we do win.
"Saracens know we have that extra game up our sleeves. You don't think they will take their eye off the ball, but it does put extra pressure on them."
Ulster: L Ludik, A Trimble, L Marshall, S McCloskey, C Gilroy; P Jackson, R Pienaar;
(1-8): K McCall, R Best (captain), W Herbst, A O'Connor, F van der Merwe, R Diack, C Henry, N Williams.
Replacements: R Herring, A Warwick, R Lutton, C Ross, R Wilson, P Marshall, I Humphreys, R Scholes.
Connacht head coach Pat Lam has made ten changes to his injury-ravaged side for Friday’s European Challenge Cup clash with Newcastle Falcons at the Sportsground (7.45).
The province lost their eight-game unbeaten record in all competitions when they were beaten by Cardiff Blues in the Pro12 last week and dropped from top spot in the league in the process.
They also paid a high price in terms of injury and ended the game without a recognised scrum half with Kieran Marmion, Quinn Roux and Craig Ronaldson all limping out early.
In all Connacht have 18 players sidelined for this game due to injuries.
Jack Carty is retained at outhalf while 21-year-old Caolin Blade is handed the number 9 shirt for his first start this season.
There is a new midfield partnership with Academy duo Rory Parata and Peter Robb named to start.
"With so many players unavailable through injury, it was certainly a challenge to piece together a match day squad."
Niyi Adeolokun is promoted to the right wing while Matt Healy, on the left, gets his first taste of European action this season. Galway man Tiernan O'Halloran, pictured above, will captain the side from fullback.
In the pack, there are just two players remaining from last week - Aly Muldowney and James Connolly, who, this week, was one of three Academy players to sign a senior contract for next season.
Prop Finlay Bealham, now the only player to have been involved in every game this season, starts in a new front row with Jason Harris-Wright and Ireland international Nathan White.
Ultan Dillane returns to the second row to partner Muldowney while Galway man Sean O'Brien earns his first ever senior start coming in to a back row with Connolly and the experienced George Naoupu at Number 8.
Danny Qualter is included among the replacements while Dave Heffernan will be required to cover the back row from the bench. Shane O'Leary and Danie Poolman have both returned from injury to take their place in the match day squad.
"With so many players unavailable through injury, it was certainly a challenge to piece together a match day squad,” said Lam.
"Newcastle will bring their own strengths and we are expecting a very physical battle. Despite all the changes, If we work together as a team and stick to our structures, we'll increase our chances of getting the job done."
Connacht: T O’Halloran; N Adeolokun, R Parata, P Robb, M Healy; J Carty, C Blade; F Bealham, J Harris-Wright, N White; U Dillane, A Muldowney; S O’Brien, J Connoly, G Naoupu.
Replacements: S Delahunt, C O’Donnell, R Ah You, D Qualter, D Heffernan, I Porter, S O’Leary, D Poolman.