Clermont 37-5 Northampton
Clermont were never threatened at their home fortress by Northampton, who were missing Wales winger George North due to concussion.
The hosts produced an awesome performance, their speed and creativity proving far too much for Northampton to handle.
Nakaitaci evaded several tackles after being set up by Fofana to score Clermont's first try, which Brock James converted.
The Fiji-born wing touched down again at the end of a move initiated by Fofana, who scored a try following great work by full-back Nick Abendanon.
James, who scored 17 points, kicked his third conversion and two penalties to put Clermont 27-0 up at halftime, Northampton paying a heavy price for missing too many tackles.
Clermont's total domination resumed after the break with James slotting home a penalty before Abendanon dived over following a 70-metre run.
The French side were reduced to 14 men in the 58th minute when Julien Bonnaire picked up a yellow card for an infringement in a ruck but Northampton were unable to capitalise.
Prop Alex Waller did claim a late consolation try for the English champions but they were completely outclassed on the day.