Fijiian-born Semesa Rokoduguni will make his England debut on the right wing for Saturday's QBE Series opener against New Zealand at Twickenham after head coach Stuart Lancaster announced his team today.
Kyle Eastmond and Brad Barritt form a new-look centre partnership and Dave Attwood replaces the injured Joe Launchbury in the second row after returning to the squad following the birth of his first child.
The uncapped Rokoduguni has impressed for Bath in the English Premiership this season and the 27-year-old will be England’s main threequarter threat against the world champions following the injury-enforced absence of Manu Tuilagi.
"I'm delighted for Roko. Wing is an extremely competitive position, but he has pushed himself forward with his form this season and it's great to be able to give him this opportunity," said Lancaster.
Rokoduguni is one of three uncapped players in the match-day 23 with Bath team-mate Anthony Watson offering back-three cover from the bench and George Kruis of Saracens the second-row replacement.
England have selected a previously untried centre pairing of Kyle Eastmond - the Aviva Premiership's form player - and Brad Barritt.
Eastmond experienced mixed fortunes during the summer tour to New Zealand, excelling in the first Test only to be replaced at half-time of the third when his defensive frailties were exposed.
Barritt's inclusion at outside centre provides England with an insurance policy as Lancaster views the Saracens midfielder as best defensive back in the Premiership.
Jonny May of Gloucester fills the left wing slot despite a disappointing tour of New Zealand which placed his international future in doubt.
Danny Care and Owen Farrell form the half-backs with Farrell chosen despite being restricted to only two starts for Saracens this season because of a thigh strain.
England's pack, which has been decimated by injuries to the tight five, picked itself once the respective calf and thigh injuries carried by props David Wilson and Joe Marler cleared up.
Attwood was the next in line to partner Courtney Lawes in the second row after Joe Launchbury was ruled out of the entire autumn schedule with a neck problem.
Billy Vunipola has held off the number eight challenge from Ben Morgan to start in the back row with Chris Robshaw leading the team.
England host New Zealand on Saturday before facing further autumn appointments with South Africa, Samoa and Australia.
England suffered a 3-0 Test series defeat in New Zealand earlier this year, but they beat the All Blacks 38-21 at Twickenham two years ago.
England (v New Zealand): M Brown (Harlequins); S Rokoduguni (Bath), B Barritt (Saracens), K Eastmond (Bath), J May (Gloucester) ; O Farrell (Saracens) , D Care (Harlequins); J Marler (Harlequins), D Hartley (Northampton), D Wilson (Bath), D Attwood (Bath), C Lawes (Northampton), T Wood (Northampton), C Robshaw (Harlequins, capt), B Vunipola (Saracens).
Replacements: R Webber (Bath), M Mullan (Wasps), K Brookes (Newcastle), G Kruis (Saracens), B Morgan (Gloucester), B Youngs (Leicester), G Ford (Bath), A Watson (Bath).
