Wales have recalled flanker Sam Warburton and full-back Leigh Halfpenny for Saturday's Test against Australia in Cardiff.
Hooker Richard Hibbard and scrum-half Rhys Webb, who also missed this year's tour of South Africa due to injury, were also included in the starting line-up.
George North and Jamie Roberts form a formidable centre partnership and prop Paul James continues in the front row alongside Samson Lee and Hibbard.
Wales have lost their last eight Tests against Australia by single-figure margins.
"We have spoke a lot about this autumn and the year ahead and we are really excited to kick off the campaign this weekend," coach Warren Gatland said.
"We have had a couple of very hard weeks at training, the squad have been put through their paces but have come through well.
"It's good to be able to bring back a number of players who missed the last two tests, and they add to what is a very experienced side."
Wales: 15-Leigh Halfpenny, 14-Alex Cuthbert, 13-George North, 12-Jamie Roberts, 11-Liam Williams, 10-Dan Biggar, 9-Rhys Webb; 8-Toby Faletau, 7-Sam Warburton (captain), 6-Dan Lydiate, 5-Alun-Wyn Jones, 4-Jake Ball, 3-Samson Lee, 2-Richard Hibbard, 1-Paul James.
Replacements: 16-Scott Baldwin, 17-Gethin Jenkins, 18-Rhodri Jones, 19-Bradley Davies, 20-Justin Tipuric, 21-Mike Phillips, 22-Rhys Priestland, 23-Cory Allen.