South Africa duo Bjorn Basson and Chiliboy Ralepelle are to be sent home from the tour of Britain and Ireland after testing positive for a banned stimulant.
The pair were randomly tested after the Test match against Ireland in Dublin on 6 November.
RBS Six Nations Rugby, who administer the November internationals, have confirmed to the South African Rugby Union that they have tested positive for methylhexaneamine.
Basson was already due to leave the tour because of an ankle injury picked up against Wales on Saturday, but the two players will head for South Africa today under different circumstances.