Fly-half Finn Russell will miss Scotland's potentially decisive World Cup clash with South Africa after failing to shake off an ankle knock.
The influential playmaker has been key to Scotland's opening two wins over Japan and the United States but remains on crutches after injuring his ankle in Sunday's victory over the Eagles in Leeds.
Head coach Vern Cotter - who has announced 10 changes in his team to face the Springboks in Newcastle this Saturday - will now put his faith in Russell's Glasgow team-mate Duncan Weir as he seeks the win which could clinch the Dark Blues a quarter-final slot.
Scotland: Gordon Reid, Fraser Brown, Willem Nel, Richie Gray, Jonny Gray, Josh Strauss, Blair Cowan, David Denton; Greig Laidlaw (captain), Duncan Weir, Tim Visser, Matt Scott, Richie Vernon, Tommy Seymour, Stuart Hogg
