Desert Flower claimed the Betfred 1000 Guineas Stakes at Newmarket to maintain her flawless record and continue Godolphin's remarkable weekend.
Trained by Charlie Appleby, who landed the 2000 Guineas with Ruling Court on Saturday, the chestnut was the evens favourite under William Buick.
Buick was hunting for his first success in the race and the duo led the group racing on the far side as a smaller handful challenged up the near side.
Her key rival became Ollie Sangster's Flight in the final stages, but when Desert Flower met the rising ground she pushed on again and pulled clear of all contenders to prevail by a length. Sangster also saddled the third-placed Simmering.
ALL-THE-WAY!
— Newmarket Racecourse (@NewmarketRace) May 4, 2025
Desert Flower takes the @Betfred 1000 Guineas in ASTONISHING style 🏇💨 pic.twitter.com/HINIYHygRH
"I'm a very happy man. Congratulations to everyone, this means the world," Buick told ITV Racing.
"To do the Guineas double, the Kentucky Oaks and Kentucky Derby and to be a part of it, I just can't put it into words.
"It was incredible. We looked at the race beforehand, me and Charlie spoke and said we thought we'd have to make our own running.
"You saw what a versatile filly she is, we didn't think that would be a problem for her. She's genuine, she's uncomplicated. She gets organised coming out of the dip, hits the rising ground - she's all class.
"She's a beautiful filly and she may even get a little bit further.
"I think she could be (an Oaks filly), that's the race everyone was thinking of beforehand, we'll sit down and make a plan. It's been an amazing weekend for everybody."
Appleby said: "It's been an amazing weekend, it'll probably take a few days for it to really sink in.
"I wasn't too worried watching the race, we saw it in the Fillies' Mile and in the May Hill as well, she just goes through those gears.
"At one point she just looks a little bit sticky but with the dip here, especially on this quicker ground, we knew we would just have to go out and make it (the running).
"I said to get her out, get her into a rhythm and then you're sat comfortably at the top of the dip, that puts them on their heads a bit and they can stumble or find their feet.
"Great ride by William, I did speak to the team in America this morning and said 'thanks ever so much, you've put the pressure on now!' but we don't mind that. Pressure is good.
"I see no reason why she can't stretch out to the mile and a half, she does all her best work in the last furlong. She settles well, they're nice conversations to be having."