Ghaiyyath wrested away Enable's Coral-Eclipse crown with a relentless front-running victory at Sandown.
Charlie Appleby's remorseless galloper was sent off 9-4 and led after the first furlong and was never headed as he added his second successive Group One following last month's success in the Coronation Cup at Newmarket.
Enable (Evens Fav), having her first run of the campaign and absent since finishing a gallant second in last year's Prix de l'Arc de Triomphe, was held up off the pace by Frankie Dettori and could never get to the winner - eventually finishing a two-and-a-quarter-length runner-up.
Winning rider William Buick said afterwards: "He's got a huge cruising speed and he knows how to use it. He had won over a mile and a quarter, at Group Two level, but it was his first go over a mile and a quarter in a Group One and he was in a nice rhythm the whole way.
"Charlie had him in great shape. We were obviously concerned about Enable coming into the race, but it was her first run of the season and I'm sure she'll improve from the race.
"As a horse, you go with what Ghaiyyath wants to do - he's not a horse who likes to be controlled. You just sit against him, let him use his huge stride and go when he's ready.
"He's a joy to ride and a very, very good horse. As a five-year-old he's mature physically and mentally - he's becoming the finished article.
"I think a mile and a quarter will be his optimum trip - he's very fast. Sometimes when you ride him over a mile and a half you're always worried the last furlong is going to be a long one, but he keeps going.
"He's obviously very effective over both distances."
Appleby - celebrating his 45th birthday - said: "He's a horse we've always held in high regard and we've seen the performances he can put up. Obviously he'd been an emphatic winner in France and in Germany and out in Dubai, but I think the Coronation Cup win gained him a lot of fans and support.
"We were never concerned about dropping him back to the 10 furlongs today. He's got loads of pace and statistically this track suits front runners.
"We had immense respect for Enable, who I felt lost nothing in defeat - it was a great battle up the straight."
He added: "This year he seems to be taking his races better. We toyed with the idea of going for the Prince of Wales's Stakes after the Coronation Cup, but we thought we'd give ourselves an extra couple of weeks and we know this track can favour a front runner.
"The Juddmonte International at York would be up there (as a target). He's shown his versatility now, winning over 10 and 12 furlongs.
"You don't beat Enable having an easy run, so we'll see where we are over the next week and then decide whether we head to York or whether he needs a bit more time.
"There's plenty of racing coming up over the autumn, so I don't think we need to be making any rash decisions - there are plenty of options out there."
On a potential rematch with Enable in the Arc, Appleby said: "I'd rather not have to take her on!
"Last year we felt he was a potential Arc horse. Unfortunately the ground went very soft, it was a very strongly-run race and it paid in the end.
"Our plan was always to work back from another crack at the Arc. If Enable is in it, we'll just have to take her on again.
"We're delighted with today's success - I'm very pleased for the horse."
Despite the defeat, John Gosden was understandably thrilled with the effort of Enable.
He said: "I'm delighted with her. She ran a gorgeous race. We know Ghaiyyath, and as I warned everybody, it is a great front-runners track, Sandown. If he gets free on the front, as he is a fabulous horse, you are never going to get to him. We found that out in the Coronation.
"She has put in a perfect performance and has come with a lovely run. I'm delighted with the way she came there. Frankie said the last half a furlong she just needed it, so he looked after her. It is the perfect platform we were looking for for the King George (Ascot, 25 July). We were very happy.
"She enjoyed it and her zest and desire is there, but trying to get involved with a front-running horse like him was never going to be her deal. I think I did warn everybody about that left, right and centre.
"She is an older mare now and it has taken a great deal more to get her to this point, but she has run a beautiful race and I couldn't be more thrilled with her. We knew coming we were 85% and you are not going to beat a front-running horse like that around here.
"She has run the most perfect race to point towards the King George."
A'Ali (12-1) bounced back to his brilliant best to make a return to winning ways and open his account for the campaign in the Coral Charge.
Having failed to see out six furlongs on his seasonal return at Newcastle, last year's Norfolk Stakes hero appeared to appreciate the drop back to the minimum trip for this Group Three affair.
Despite being slowly away from stall one, the Simon and Ed Crisford-trained colt showed a good turn of foot once put in clear daylight by Frankie Dettori, before getting the better of favourite Liberty Beach by a length.
Ed Crisford said of his winner: "It was nice to see the horse come back. Six furlongs at Newcastle on the all-weather didn't work out. He came out of the race really well. He was training well and back at five he did it really well.
"He is a triple Group Two winner, but he went to America (for the Breeders' Cup) and had one bad run and he became forgotten quickly.
"He is a good horse and he deserves to be where he is. He is not the biggest, but he has got an engine."
Equally delighted with the performance was Dettori, who was celebrating a fourth victory aboard A'Ali.
He said: "He has not grown much from two to three, but what he lacks in stature he makes up for in heart and guts.
"The number one draw here is the best draw on the sprint track, but you have got to get the splits. I was determined to stay on the rail. A furlong and half out I had to pull him out though and he did the rest. He got his head down like a terrier and he wants to win.
"I'm pleased he has won a Group race at three."
A clash with recent King's Stand Stakes winner Battaash looks to be on the cards for A'Ali, with Crisford pointing towards the King George Qatar Stakes at Goodwood next for the Society Rock colt.
He added: "He will head to Goodwood now for the King George, as there are not many places to go, then we will look at the Nunthorpe.
"It was a really good race today though, as there were some proper horses in there and he was taking on the older horses. He had to be at his best today and he was."
Dashing Willoughby (11-4) moved a step nearer to an end-of-season outing in the Melbourne Cup following a battling success in the Coral Henry II Stakes.
Last year's Queen Vase winner made it two wins from as many starts this season, following up his comeback Listed victory at Newmarket in the rescheduled Group Three.
Displaying a willing attitude for Oisin Murphy, the Nathaniel gelding found plenty on his return to two miles to keep Spanish Mission at bay by a length and a quarter.
Trainer Andrew Balding said of his winner: "It was really good. We made a bit of a mess of it last year running him too many times. Just with a bit of gap between his races seems to really suit him and he was obviously in good form today.
"These stayers put their heart and soul into the races and they take a lot out of themselves. I probably hadn't appreciated that with him last year and we probably went to the well a couple of times too many.
"He looked good at Newmarket last time. It is very pleasing, as the owner Mick Mariscotti was the financial director at Coral and it will give him great delight to taking Coral's sponsorship money."
Gussy Mac (10-1) continued his climb through the ranks with a tenacious success in the Coral Beaten By A Length Freebet Dragon Stakes.
After building on a promising debut at Newmarket with victory last time out at Wolverhampton, the Dark Angel colt took another step forward to claim top honours in the Listed prize.
Doing all his best work late on in the five-furlong contest, he pulled out plenty to defeat Significantly by half a length.
Teal said: "That wasn't bad for the biggest drifter of the day!
"It all went wrong on his debut as he fluffed his lines in the stalls, but he made up a lot of ground.
"At Wolverhampton he was as green as grass and he was still very green there today. Jack (Mitchell) said he stumbled and lost his way a bit, then when he hit the rising ground he knuckled down and stayed on nicely.
"It is great to see him fulfil the potential we thought he had."
A step up in class and trip is likely to be on the agenda, with Teal earmarking the Group Two Richmond Stakes over six furlongs at Goodwood as the next target.
There was a French-trained success in the Listed Coral Gala Stakes, with Magny Cours (5-2) obliging for Andre Fabre and William Buick in the Godolphin colours.