Chacun Pour Soi has been declared a non-runner for this afternoon's Champion Chase at Cheltenham.
It is another significant loss to the race after the withdrawal of Altior earlier in the week.
The Willie Mullins-trained horse has been ruled out due to a vets certificate, adding to the trainer's woes after a disappointing opening day of the festival.
Chacun Pour Soi reportedly has an abscess.