Cheltenham Gold Cup third Anibale Fly has been given the green light to take his chance in the Randox Health Aintree Grand National on Saturday week.
Tony Martin's charge produced a career-best performance to pick up minor honours in the blue riband behind Native River and Might Bite, and is officially 9lb well-in at the weights for the world's most famous steeplechase.
Connections considered the Irish Grand National or waiting for the Punchestown Gold Cup, but Frank Berry, racing manager to owner JP McManus, has confirmed him an intended runner on Merseyside.
Berry told Press Association Sport: "At the moment, as long as everything goes well over the weekend and Tony is happy with him, the plan is for him to go there (Grand National)."
Anibale Fly is set to lead a four-strong McManus-owned contingent into battle, as he seeks his second victory in the race after Don't Push It's memorable triumph under Tony McCoy in 2010.
Berry added: "There's Minella Rocco and, all being well, Carlingford Lough and Regal Encore will run, too.
"They're all in good form at the moment and the four of them will run if they get through the weekend and next week."
Anibale Fly is a general 12-1 shot for the Grand National, with Minella Rocco also prominent in the market at a best-priced 16-1.
Regal Encore and Carlingford Lough can be backed at 33-1 and 66-1 respectively.
As De Mee, who was available at 50-1, has been ruled out of Aintree due to a leg injury.
Trainer Paul Nicholls had set his sights on the four-and-a-quarter-mile feature with As De Mee after he finished fifth in last year's Topham Chase and won the 2016 Grand Sefton over the National fences.
However, a leg problem has scuppered those plans and Nicholls is hoping he will be back for next year's National instead.
He told his Betfair blog: "I'm disappointed to report that As De Mee is out of next week's Grand National after sustaining a minor leg injury.
"It is tough luck on his owners Andy Stewart, his family and Dame Judi Dench who were looking forward to a big run from him as he has smart form over the Aintree fences.
"I've been preparing As De Mee all season with the Grand National in mind.
"Hopefully he might get there next year if he is back in full training by Christmas"