Vicente won a thrilling renewal of the Coral Scottish Grand National at Ayr to put Paul Nicholls back on top in the race for the British trainers' championship.
Nicholls was trailing Willie Mullins by more than £110,000 before the start of play, but a treble, culminating in Vincente (14-1) landing the feature, has seen him regain the championship lead.
Mullins' hopes of winning the big race for Ireland came to a premature end as Measureofmydreams crashed out in the early stages.
Then Folsom Blue, trained by Mouse Morris, who sent out the winners of the English and Irish Nationals, exited six out to end dreams of a historic hat-trick.
In the straight for the final time, it looked as though Seeyouatmidnight was going to strike for Scottish Borders trainer Sandy Thomson.
However, Vincente was brought with a perfectly-timed run to lead after jumping the last.
Alvarado (25-1) finished with a flourish to claim second place, two-and-three-quarters lengths behind the winner.
Seeyouatmidnight (14-1) was a head away in third, with Royale Knight (20-1) fourth.
Vyta Du Roc, the 8-1 joint-favourite, finished fifth.
Nicholls said: "I've had this in mind for a long time. We kept him fresh all winter, didn't run him from the December meeting at Cheltenham, and then went to the Festival for the four-miler, where he was arguably a bit unlucky in running, and then today was the day really.
"He stays well, a flat track suits him well and he could just turn out to be an Aintree horse next season and that's probably where we will aim him.
"It means a lot on days like these, everybody has worked hard all winter and it hasn't always gone to plan this year.
"(It's) a huge turnaround (in the title race), we were 180 grand down this time last week, but we just kept chipping away and we needed a big result today and we've had some good winners. They've been a massive help.
"We've just got to keep going all week now and Sandown is going to be a big day," he told Racing UK.
Scottish Grand National (4.10 Ayr) result:
— RTÉ Racing (@RTEracing) April 16, 2016
1 Vicente 14-1
2 Alvarado 25-1
3 Seeyouatmidnight 14-1
4 Royale Knight 20-1
5 Vyta Du Roc 8-1JF
Twiston-Davies was also aboard Le Mercurey (11-2), who floored hot-pot Bristol De Mai by seven lengths in the Jordan Electrics Ltd Future Champion Novices' Chase.
"We always believed in him. Cheltenham was wrong, he doesn't like it there. He's better on a flat, galloping track," said Nicholls.
Sean Bowen was in the saddle as Vivaldi Collonges defied top weight in the Weatherbys Private Bank Novices' Limited Handicap Chase.
"He is a good horse, he's won three from four this year now," said Nicholls.
"He was in the Scottish National, but that was a year too soon. I'll be looking at the Becher Chase and look forward from there."
Gibbes Bay (5-1) tied up the Nicholls foursome, and a Twiston-Davies treble, by making a winning debut in the Skyform Group Standard Open National Hunt Flat Race.
It was also a landmark day for Nicholls' former assistant Dan Skelton as he reached 100 winners in a season for the first time thanks to a double with Ch'Tibello (8-1) and Two Taffs (5-2 favourite).
The latter provided the landmark success for the trainer with a three-length verdict over Missed Approach in the Ayrshire Hospice Land O'Burns Starlight Walk Handicap Hurdle.
Ch'Tibello had put the Skelton team within touching distance of the century when landing the QTS Scottish Champion Hurdle by a length and three-quarters.
Both horses were ridden by his brother Harry, who is now just two short of his maiden century.
Outsider of seven, De Faoithesdream, sprang a 20-1 surprise in the Scotty Brand Handicap Chase.
Paul Moloney produced the Evan Williams-trained 10-year-old to lead approaching the final fence and win by a length and three-quarters from Ultragold.
The Nicholls stable had to settle for second with Alcala as David Noonan drove home the David Pipe-trained Impulsive American (8-1) in the Ortus Homes Racing Excellence 'Hands And Heels' Finale Handicap Hurdle.
