Silviniaco Conti will face six rivals when he bids for back-to-back triumphs in the Betfred Bowl at Aintree on Thursday.
The nine-year-old disappointed when favourite for last month's Cheltenham Gold Cup and champion trainer Paul Nicholls will be hoping his dual King George winner can get back to winning ways on Merseyside, just as he did 12 months ago.
The Jonjo O'Neill-trained Holywell was three places ahead of Silviniaco Conti when fourth in the Gold Cup and renews rivalry.
He was a brilliant winner of the Mildmay Novices' Chase over the course and distance last season.
Ma Filleule won over the Grand National fences in last year's Topham Chase and is a major contender for Nicky Henderson off the back of finishing second in the Ryanair Chase.
Menorah is a course winner for Philip Hobbs and arrives at Aintree fresh, having been off the track since Christmas.
David Pipe's Ballynagour, the Alan King-trained Smad Place and Vukovar from Warren Greatrex's stable complete the field.