Cirrus Des Aigles will not run in the Longines Hong Kong Cup at Sha Tin on Sunday after suffering a setback.
The Corine Barande-Barbe-trained six-year-old sustained a tendon injury during light work on Thursday.
A statement issued by the Hong Kong Jockey Club read: "Cirrus Des Aigles, a declared starter in the Longines Hong Kong Cup, has been found to have a left fore tendon injury.
"Accordingly, Cirrus Des Aigles has been withdrawn from the stated race."
Cirrus Des Aigles was the short-priced favourite to win the Hong Kong Cup after he got to within a length and three-quarters of Frankel in his defence of the Champion Stakes at Ascot in October.
Barande-Barbe said: "It's disappointing to miss the race but he is not right and will need a rest.
"I think it is not too serious and you will see him again next year, I hope.
"We had to stop now to ensure things did not get worse and we will give him the time he needs.
"I would love to come back to Hong Kong. I very much want to win here."
Connections of Carlton House are "upbeat" about his chances in the Cup following a satisfying breeze on Friday morning.
The Queen's four-year-old will be having his final run for Michael Stoute before he is transferred into the care of Australian trainer Gai Waterhouse.
Stoute said: "He had a nice, steady four-furlong workout and came through it well.
"He's travelled well and he looks to be in good shape to my eye."
John Warren, racing manager for the Queen, said: "Everyone around Carlton House is upbeat, including his jockey Ryan Moore.
"Although he hasn't had much overseas travelling experience he seems to have taken everything in his stride.
"He's got a good draw, this is his best distance, and ticks are in all the boxes.
"Ryan will be taking his hood off once he is in the stalls, which helps to settle him.
"I spoke to The Queen (on Thursday) and she is really looking forward to the race and to Carlton House's subsequent ventures in Australia."
Dancing Rain, trained by William Haggas, is one of a clutch of European raiders with strong claims in the Hong Kong Vase.
The 2011 Oaks heroine has had just one previous run this year, when an honourable third in the British Champions Fillies' And Mares' Stakes at Ascot in October.
Maureen Haggas, wife of the Newmarket handler, said: "She seems to have grown up a bit mentally since last year.
"She's fresh and should like the ground here a lot better than she did at Ascot on her last start.
"That was her first run in a long time, and all things considered she ran well - hopefully she'll come on for that run."
Canadian International winner Joshua Tree also takes his chance for the Marco Botti team.
Botti said: "He's in good order, despite having had a long season, but he's such a consistent horse.
"He'll be up on the pace as always but I don't think it's necessary for him to lead."
Dandino finished second in the Canadian International at Woodbine in October and renews rivalry with Joshua Tree.
Trainer James Fanshawe said: "Everything has gone well so far, and he seems very well.
"He's taken everything in his stride so far."
Dunaden won the Vase 12 months ago, but must respond positively following a disappointing run in his defence of the Melbourne Cup last month.
Trainer Mikel Delzangles said: "The horse is very well.
"I'm not sure about the pace in the race but he's drawn well and I would have no problem if he was sitting behind the leader with cover.
"He doesn't have to get too far back."
Red Cadeaux had a busy November, finishing eighth in both the Melbourne and Japan Cup, and again represents Newmarket trainer Ed Dunlop.
The six-year-old gelding claimed third place in the Vase last year.
Dunlop said: "He's ticking along OK and his form is better than it looks.
"He was the first European home in the Japan Cup on ground which was too firm for his liking - don't underestimate how good the Japanese horses are.
"In the Melbourne Cup, he just got too far back with the pace against him.
"I'm not doing a lot with him - he only ran 10 days or so ago in Japan - and he appears to be in good shape.
"I don't know if he can win but I hope he'll be in the mix."
Sea Moon is also giving off the right signals following a gentle workout on the Sha Tin turf course on Friday.
Stoute said: "That was just a nice breeze - the horse is well."