Makfi, this year's 2000 Guineas hero, has been retired to stud after suffering a bout of ringworm.
The Mikel Delzangles-trained three-year-old was a hugely impressive winner of the Newmarket Classic in May, and enjoyed further Group One glory by defeating the might Goldikova in the Prix Jacques le Marois at Deauville.
Although he was disappointing in the Queen Elizabeth II Stakes at Ascot last month, connections had been considering a possible trip to the Breeders' Cup.
He will instead take up stallion duties at Tweenhills Stud in Gloucestershire.
‘He came back from Ascot with a little bit of ringworm from Ascot and he has been retired to stud,’ confirmed Delzangles.
‘He's been a great horse to train this season and we have had a great year.
‘It will be difficult to find another one like him, but we will try.’