Deaton Registe and Dearbhaile Brady will make their European Championships debuts at the Para Swimming European Championships from 21 to 27 April in Madeira.
The Irish team was announced for the Portuguese island event, including Ellen Keane, who will be appearing at what will be her final major regional championships ahead of her planned retirement this summer.
The championships will offer swimmers an important test ahead of the Paralympic Games in Paris later in the year.
Registe is the newest member of the Ireland team and this will be the first major championship for the Lisburn swimmer, where he will take on the 100m breaststroke (SB14).
Sixteen-year-old Dearbhaile Brady will be making her second major championships appearance for Ireland; the young Derry swimmer will be competing in three of the same events as her team-mate Nicole Turner and four events in total.
Keane leads the team as the seasoned veteran, with four Paralympic Games under her belt and one more on the horizon.
Winner of paralympic gold in Tokyo, Keane will be contesting for a place on the podium in her two events: 100m freestyle (S9) and 100m breaststroke (SB8).
Turner will also bring great experience to the team, competing in what will be the third European Championships of her career. The paralympic silver medallist will compete in four events over the week-long event.
Tokyo paralympian and world champion Róisín Ní Riain will be looking to impress at her second Europeans having made her debut in Madeira in 2021 where she won a bronze medal, made five finals and was fourth in 100m freestyle and 100m breaststroke.
Ní Riain will take to the pool for five events over the course of the championships.
Tokyo paralympian Barry McClements will contest the 100m butterfly and the 100m backstroke in the S9 category.
"The team have been working hard during the winter season, been away at training camps both as a national team and with home programs so their preparation for Paris is going really well," said para swimming head coach, Hayley Burke.
"This European Open Championships provides us with an opportunity to step up midway through the season and assess where we are currently and what we need to do moving into Paris. This is a strong team for Europeans so we're looking forward to racing fast and seeing some of our competitors in action too."