The Minnesota Vikings powered to the NFC North title with a 34-7 victory over the injury-hit Cincinnati Bengals that keeps them on course for a possible first-round bye in the play-offs.
Mike Zimmer's men won the division crown for the second time in three years as they bid to be the first team ever to reach a Super Bowl in their home ground.
The Vikings were expertly marshalled by quarterback Case Keenum, who threw for 236 yards and two touchdowns, while Teddy Bridgewater made his long-awaited return from injury late in the game.
The return of Aaron Rodgers from collarbone surgery could not prevent the Green Bay Packers from slipping to a 31-24 loss to the Carolina Panthers.
Rodgers was intercepted on three occasions for the first time since 2009 but also threw for three touchdowns to turning a 31-17 deficit into the chance to draw level, only for Geronimo Allison to fumble at a critical stage.
The Jacksonville Jaguars thumped the Houston Texans 45-7 to end their decade-long wait for play-off qualification.
Quarterback Blake Bortles was outstanding as the Jaguars eased home with a quality all-round performance, completing 21 of his 29 passes for 326 yards and three touchdowns.
The Philadelphia Eagles secured a first-round bye after dispatching the New York Giants 34-29 that maintains their ambition as finishing as NFC top seeds.
The Giants had a late chance to snatch victory only for Eli Manning's pass to elude tight end Evan Engram.