Eric Boullier, McLaren's under-fire racing director, has resigned from his post with immediate effect.
Frenchman Boullier joined McLaren in 2014, but has overseen the British team's worst run in their 52-year history.
Gil de Ferran, a former IndyCar champion, takes up the new role of Sporting Director, while Andrea Stella, who moved to McLaren with Fernando Alonso from Ferrari, is promoted to Performance Director.