Waterford manager Liam Cahill is "anxious" about the fitness of Austin Gleeson, Shane Fives and Conor Prunty ahead of the Munster SHC opener against Clare in less than a fortnight.
Former hurler of the year Gleeson was substituted with an ankle problem in the win over Tipperary on Sunday, while captain Prunty and defenders Fives both limped off with quad injuries.
Cahill is without talismanic defender Tadhg De Burca for the season, most likely, following the cruciate injury suffered in last year's All-Ireland final defeat, but the Déise have made light of absentees and retirees during a strong league campaign.
However the loss of this trio ahead of their championship meeting with the Banner would be a huge blow.
"Very early yet to tell, but they'd all be little concerns for me now to be honest," Cahill told RTÉ's Sunday Sport when asked about the injuries.
"The backroom team and medics will work hard on them during the week. When you have quad muscles and ankles and stuff it is never good two weeks out.
"A lot of these injuries now are three and four week jobs, hence we took off a few guys because we couldn't persist with it when they were feeling little strains," added Cahill.
"It will be an anxious enough time now for me next week until we get a handle on what's happening," said Cahill, who is hopeful he can find adequate replacements among the large number of players given game time in past month, should they be needed.
"Throughout the league we have looked at 35 players. So, players are injured they're injured and there is nothing we can do about that only try and replace them with players who are equally as good."