Tomas Brady, star centre-back on last year's Leinster Championship-winning Dublin minor hurling team, will make his senior inter-county debut against Wexford in Sunday's Walsh Cup clash at Parnell Park.
Manager Tommy Naughton, who assumed full-time control of the Dubs in October having previously been in charge in a caretaker capacity, will start nine of the starting XV that lined out in last July's Championship victory over Laois in Dr Cullen Park.
The win against the midlanders preserved Dublin's status as a Tier One county.
Brady is one of two Under-21 dual players on the team - wing forward Eoin Moran being the other - who are part of the Dublin U-21 panel currently preparing for Saturday week's Leinster Championship fixture with Kildare.
Naughton is unable to call on corner forward Emmet Carroll, who has opted out of the panel, while Keith Wilson has decided not to rejoin the set-up despite playing against Tipperary in a recent challenge match.
Liam Ryan (shoulder) and John McCaffrey (groin) and Cormac O'Brien (knee) are also nursing injuries.
DUBLIN (SH v Wexford): G Maguire; P Brennan, K Ryan, T Brady; Derek O'Reilly, R Fallon, A de Paor; D Sweeney, M Carton; E Moran, D Russell, S McDonnell; T McGrane, D Curtin, K Flynn.