Irish interest at the Ford Championship came to an end as Leona Maguire and Lauren Walsh both missed the cut, while Nelly Korda holds a two-shot lead at Whirlwind Golf Club in Arizona after a seven-under-par 65 saw her reach 16 under at the halfway point.
Maguire's stalling 72 meant the Cavan woman finished on four under, missing the cut by a single shot.
Walsh also registered a 72, which took her to one under, as the 25-year-old failed to make the cut in a second consecutive LPGA Tour event.
Korda's round, which featured an eagle, marked her career-best 36-hole score.
She is two shots ahead of defending champion Hyo Joo Kim, as the South Korean followed her opening 61 with a 69.
New Zealand's Lydia Ko, the first-round leader after a career-low round of 60, stumbled to 71 and is in a tie for third place at 13 under.
Also at 13 under are Jenny Bae, who carded a 65 on Friday, and Japan's Minami Katsu, who produced a 66 in the second round.
Korda, who won the Phoenix-area tournament two years ago at a different course, made four birdies on the front nine and had her lone bogey of the day at the par-three sixth hole. She was still three under for the day before reaching the green in two on the par-five 12th hole and sinking a long eagle putt.
She added two more birdies before closing with consecutive pars.
"Overall hit it really good off the tee," said Korda, who earned her 16th career LPGA win last month at the Tournament of Champions. "Took advantage where I could. Rolled in a nice eagle, too.
"Hit it nicely into the par-fives, which obviously is an advantage out here. But overall, you know, just I would say I have no complaints, yeah."