England's Bronte Law and Mel Reid were Round-of-16 casualties at the Bank of Hope LPGA Matchplay tournament at Shadow Creek in North Las Vegas on Saturday.
The 87th-ranked Law ran into in-form American Danielle Kang, the world No 6, who made it four wins from four matches by winning 2up.
And having advanced to the knockout stage through a playoff against Spain's Azahara Munoz, Reid lost heavily to Australia's Minjee Lee, 5&4.
Law battled hard to stay in her match. After going two holes down by bogeying the sixth, she drew level by taking holes 12 and 14 before Kang claimed the last two holes by going par-birdie.
The 34th-ranked Reid was outclassed in claiming just one hole - the 10th - against world No 11 Lee, who was four-up after nine.
After Kang and Lee were eliminated in the quarter-finals, the last day was set to begin with semi-finals pitting Thailand's Ariya Jutanugarn against American Ally Ewing and German Sophia Popov against China's Feng Shanshan.