Four-time major winner Brooks Koepka has withdrawn from the 2021 Players Championship due to a knee injury.
"Brooks strained his right knee and he is scheduled to further consult with doctors this week to receive a more extensive evaluation and outlook," said Blake Smith, Koepka's manager.
"We will be able to provide additional updates and information as we learn more."
He has previously struggled with an injury to his left knee which saw him sidelined for three months in 2019 and forced him to miss last year's US Open.
The 30-year-old also needed on-course treatment to his hip during his title defence at the US PGA Championship in 2020.
Eight-time PGA Tour winner Koepka is currently 12th in the Official World Golf Ranking.
He finished in a tie for second place at the World Golf Championships-Workday Championship at The Concession on 28 February and won the Waste Management Phoenix Open earlier in the month.
Kopeka will be replaced in the 154-player field at The Players Championship by Anirban Lahiri of India, provided a player not otherwise exempt wins the Arnold Palmer Invitational.
The Players Championship begins on Thursday at TPC Sawgrass in Ponte Vedra Beach, Florida.