After more than a decade on tour, Dubliner Peter Lawrie has lost his European Tour card after missing the cut on eight over par at the Perth International in Australia.
Gareth Maybin also faces a return to Tour school after missing the cut on level par.
Kevin Phelan, who needs at least a top-four finish, still has a chance of saving his card after making the cut on three under.
The leading Irish player is Damien McGrane on four under after two rounds, eight shots off the lead held by Scotland's Peter Whiteford.