Galway produced a stunning display to score a record win over a Tyrone side that finished with 13 men at Tuam Stadium.
The Tribesmen, having played with the breeze, led by 0-12 to 0-6 at the break with all six forwards scoring from play as they moved the ball at pace.
Shane Walsh led the way for Tribesmen but Tyrone responded with a couple of good efforts from the impressive Cathal McShane at full-forward.
Tyrone suffered a big blow seven minutes from the break when Kieran McGeary was sent off for a challenge on Galway wing-forward Eamonn Brannigan and they lost Frank Burns to a second yellow card midway through the second-half.
Tyrone rallied after the break and three pointed frees from Darren McCurry gave them hope but they suffered a big blow when McShane was stretchered off with a serious leg injury.
Galway hit back and when Damien Comer was fouled, Walsh stepped forward and blasted home the penalty for the hosts to take a 1-14 to 0-11 lead into the final quarter.
Galway used the extra space superbly and Tyrone just could not contain them as Padraic Joyce's men picked off points from all angles.
Brannigan and Adrian Varley finished with four points each from play and they sealed the win when substitute Paul Conroy finished low into the right corner from a tight angle after the Tyrone defence was again opened up.
Earlier, Galway used the ball at pace to build up their opening half advantage with Corofin’s Ronan Steede landing three points from play from midfield in addition to all six forwards scoring.
In contrast, Tyrone just did not have the firepower, especially when McShane was carried off and they depended on the accuracy of McCurry for scores.
But that was never going to be enough as Galway pulled away to outscore them by 2-11 to 0-1 in the final 20 minutes to send out a clear message that they are going to be a force to be reckoned with this season.
Galway: Connor Gleeson; Sean Kelly, Sean Mulkerrin, Johnny Heaney; Gary O’Donnell, Liam Silke, Cillian McDaid; Ronan Steede (0-03), Cein D’Arcy; Eamonn Brannigan (0-04), Damien Comer (0-02), Michael Daly (0-02); Robert Finnerty (0-01), Shane Walsh (1-08, 1-00 pen, 0-05f), Adrian Varley (0-04).
Subs: Tom Flynn for D’Arcy (27), Paul Conroy (1-01) for Finnerty (47), Dessie Conneely for M Daly (59), Conor Campbell for O’Donnell (59), Sean Andy O Ceallaigh (65).
Tyrone: Niall Morgan; Niall Kelly, Ronan McNamee, Liam Rafferty; Tiernan McCann, Rory Brennan, Peter Harte; Colm Cavanagh, Brian Kennedy; Kieran McGeary (0-01), Niall Sludden (0-01), Darren McCurry (0-07, 0-06f); Frank Burns, Cathal McShane (0-02), Conor Meyler.
Subs: Padraig Hampsey for Cavanagh (36), Michael McKernan for Kelly (36), Mark Bradley (0-01) for McShane (39), Ben McDonnell for Kennedy (54), Conal Grimes for McCann (62).
Referee: Conor Lane (Cork)