Roscommon will be without Shane Killoran and Ronan Daly for the remainder of the Allianz Football League campaign.
It is a significant blow for manager Anthony Cunningham with the Rossies bottom of Division Two after drawing to Laois and losing to Fermanagh at the weekend.
Midfielder Killoran suffered a suspected broken ankle in the first minute of Sunday's defeat in Enniskillen, while Daly also faces a long spell on the sidelines after sustaining damage to his spleen in a collision at training last week.
