Oisin Mullin will make his first appearance for Mayo since deciding against a move to Aussie Rules when James Horan's side travel to Croke Park on Saturday evening (live on RTÉ 2) to take on Dublin.
The two-time Young Footballer of the Year is one of seven changes to the team that defeated Monaghan last weekend, with the Kilmaine man named at wing-back for the Allianz Division One clash.
Doubts surfaced around Christmas whether the dynamic defender would make the career switch.
Last month he confirmed the change of heart, saying that while "going to Australia to play professionally was a really interesting opportunity and it was something I wanted to research and consider in detail" he had decided to remain in Ireland.
Mullin was part of the Mayo panels that reached the 2020 and 2021 All-Ireland SFC finals, starting both deciders as James Horan's side lost to Dublin and Tyrone respectively at Croke Park.
Elsewhere on the Mayo team, All-Star Matty Ruane will make his first league start, Kilmeena's Jack Carney starts at wing-forward and Paul Towey gets the nod ahead of Jason Doherty in attack.
Rory Brickenden and Donncha McHugh replace Padraig O'Hora and Paddy Durcan in defence.
Meanwhile, Dublin manager Dessie Farrell has made one change from the side that lost to Kerry last time out.
Ryan Basquel, who came on and scored a point in Tralee, replaces Cameron McCormack in the full-forward line.
Dublin: Evan Comerford, Lee Gannon, David Byrne, Darragh Conlon, Sean Bugler, John Small, Sean McMahon, Brian Fenton, Tom Lahiff, Niall Scully, Ciaran Kilkenny, Brian Howard, Lorcan O'Dell, Ryan Basquel, Dean Rock
Mayo: Rob Hennelly; Lee Keegan, Rory Brickenden, Michael Plunkett; Oisín Mullin, Stephen Coen, Donnacha McHugh; Matthew Ruane, Jordan Flynn; Bryan Wals, Diarmuid O’Connor, Jack Carney; Paul Towey, Ryan O’Donoghue, Aiden Orme
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