Steve Smith and David Warner have been banned for 12 months over the Australia ball-tampering scandal, according to reports.
Cameron Bancroft, the batsman who was caught on camera attempting to use tape and dirt to change the condition of the ball during the third Test against South Africa, has reportedly been banned for nine months.
The severe punishments are expected to be confirmed by Cricket Australia on Wednesday.
Smith and Warner have also been banned from taking part in this year's Indian Premier League.
The duo had already stepped down from their roles as captain of their franchises, Smith at Rajasthan Royals and Warner at Sunrisers Hyderabad, in the wake of the scandal.
But the IPL has also now suspended the pair.
"They (Cricket Australia) have banned two players and we are also barring these two players from this year's IPL," IPL chairman Rajeev Shukla told the Hindustan Times.
All three disgraced players involved have been sent home ahead of the fourth and final Test in Johannesburg, with Matt Renshaw, Glenn Maxwell and Joe Burns called up as replacements.
Tim Paine, who took over from Smith as captain mid-match in Cape Town as the furore began to unfold, was officially appointed as captain of the Test team on Tuesday.
Smith and Australia vice-captain Warner have also relinquished the captaincy of their Indian Premier League sides.
It is a heavy price to pay for the players, especially Smith, the world's number one ranked Test batsman who will now lose a year of his career.
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Warner has emerged as the apparent ringleader, with CA charging him with "development of a plan to attempt to artificially alter the condition of the ball".
The 31-year-old will not be considered for a team leadership position in the future, CA added, while Smith and Bancroft will not be considered for such roles until 12 months after their bans end.
Smith, 28, was charged with "knowledge of a potential plan to attempt to artificially alter the condition of the ball".
Bancroft, 25, playing in only his eighth Test, was charged with "knowledge of the existence of, and being party to, the plan to attempt to artificially alter the condition of the ball using sandpaper", and "carrying out instructions to attempt to artificially alter the condition of the ball".
All three players will be permitted to play club cricket, and will be encouraged to do so, to maintain links with the cricket community.
In addition, all three players will be required to undertake 100 hours of voluntary service in community cricket.
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Meanwhile, a review into the culture of the Australian cricket team, brought into sharp focus in the wake of the scandal, will be published in due course.
Sutherland said: "The sanctions we have announced are significant for the individuals involved. That is why the process has had to be thorough to ensure that all relevant issues have been examined.
"I am satisfied that the sanctions in this case properly reflect a balance between the need to protect the integrity and reputation of the game and the need to maintain the possibility of redemption for the individuals involved, all of whom have learned difficult lessons through these events.
"As indicated, Cricket Australia will provide more details of an independent review into the conduct and culture of our Australian men's team in due course."