Tyson Fury has announced he will fight Derek Chisora at the Tottenham Hotspur Stadium in London on 3 December, despite already beating the veteran twice.
The first was via a unanimous decision at Wembley in July 2011 and a retirement win three years later at London's ExCel.
The move comes following the collapse of talks for a prospective bout between Fury and Anthony Joshua earlier this month.
Chisora's corner would not let him fight on in their second meeting in 2014, such was the punishment he sustained throughout the contest.
Fury has since gone on to become a two-time world champion while his opponent is 38 and has lost three of his last four fights.
The champion was last in action in April when he stopped Dillian Whyte inside six rounds.
Whyte also has two victories over Chisora as part of 12 defeats for Fury's challenger.
Oleksandr Usyk holds the remaining heavyweight titles and is likely to face Fury next year.
Fury's promoter Frank Warren said: "I am thrilled to be delivering a Tyson Fury world title defence in front of the British fans in London.
"Tyson clearly conquered America across his trilogy with Deontay Wilder and there is also huge demand to stage his fights from sites across the world.
"Tyson wanted to fight in his home country again this year following his special night at Wembley Stadium in April. This brings us to the magnificent Tottenham Hotspur Stadium and a match against an old rival in Derek Chisora.
"Derek, also a big favourite with British fans, has reinvented himself in recent years and Tyson has long stated his wish to fight him for a third time."
Warren reiterated Fury's plan to take on Anthony Joshua's conqueror Usyk in a unification fight in the first part of next year.
The Ukrainian previously indicated he had no desire to fight before the new year.
"Tyson can't afford any slip-up in this fight as he has the much-publicised undisputed match-up with Usyk in the new year which we're really looking forward to," added Warren.
Daniel Dubois will make the first defence of his version of the WBA title against Kevin Lerena on the undercard