Katie Taylor will face Natasha Jonas on 1 May with the Bray boxer's undisputed world lightweight titles on the line.
Almost a decade on from their famous meeting at London 2012, Taylor will battle the Liverpool-born boxer again on the same card as heavyweight fighters Derek Chisora and Joseph Parker.
Taylor famously beat Jonas in their lightweight quarter-final in front of a crowd generating a record 113.7 decibels of noise at London's ExCel Arena before going on to claim Olympic gold.
Since then Taylor has won professional world titles in two weight divisions while Jonas fought a thrilling world super-featherweight title draw with Terri Harper last summer.
Taylor, who finished 2020 by being named Ring Magazine's 'Female Fighter of the Year' for the second year in succession, said: "Natasha proved in her last fight that she is still performing at the highest level so it's a great challenge for me and I'm really looking forward to it.
"People still talk about our fight in the 2012 Olympics and I think that proved to be a real eye opener for people in terms of what women's boxing is all about."
Chisora's bout against former WBO champion Parker will mark his first fight since his defeat to Ukraine's Oleksandr Usyk at Wembley last October.
